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NMF Hydrator Barrier Repair Science

Benefits

  1. Tightens and smooths skin texture
  2. Reinforces the skin barrier
  3. Minimizes trans-epidermal water loss
  4. Allows Karotinocyes (skin cells) to hold onto water

learn more below! ↓

Ingredients:

Distilled water, Squalane, C12-15 alkyl benzoate, Propanediol 1 3, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Hydrolyzed silk protein, Glycerin, Ceramide NP, Ceramide AP, Ceramide EOP, Beta glucan, C15-19 alkane, colloidal oatmeal,hyaluronic acid, polyglyceryl-6 laurate, polyglycerin-6, Sodium lauroyl lactylate, carbomer, Benzylalcohol, phenoxyethanol, Acetyl hexapeptide-3,Hydroxypropyl cyclodextrin, palmitoyl tripeptide-38, Phytosphingosine, Palmitoyl dipeptide-5, diaminobutyloyl hydroxythreonine, palmitoyl dipeptide-5, diaminohydroxybutyrate,scorbic acid, Hydrolyzed collagen, Palmitoyl tripeptide-5, cholesterol, Tremella mushroom, Tetrapeptide 30, Tetrapeptide-21,Nano liposomal resveratrol, Sodium benzoate, Potassium sorbate

1: Tightens and smooths skin

AIREtech PD5(2) peptides:

palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine (tetrapeptide), palmitoyl dipeptide-5 diaminohydroxybutyrate (tripeptide):

Leads to skin compactness, reduces appearance of wrinkles, increases tonicity & firmness. Makes the skin look firmer, younger and rejuvenated and nourished. Clinical studies in vitro and in vivo have shown significant skin improvement. (Figure 1)

Acetyl hexapeptide-3:

Works through a unique mechanism which makes the skin looks firm and tight. Can reduce the appearance of superficial facial lines and wrinkles with regular use.

2: Hydrates the skin from within

Hyaluronic Acid:

Responsible for tissue hydration, lubrication and tissue stability. Holds 500 times its own weight in water. Most powerful moisturizer and humectant available. (Figure 1)

3: Strengthens the skin barrier

AIRE-CPC Tri-Lipid Complex

Ceramides phytosphingosine and cholesterol:

The Ceramides we are using are Ceramide NP, Ceramide AP and Ceramide EOP. Phytosphingosine is a phospholipid, a fat that’s naturally found in the outermost layer of the skin. It’s one component of the skin barrier, along with ceramides, cholesterol, and fatty acids.

Beta Glucan:

Antioxidant that strengthens the skin barrier and minimizes transepidermal water loss

Colloidal oatmeal:

soothes stressed, blemished and irritated skin

Tetrapeptide-21:

stimulates collagen growth and skin repair.

4: Diminishes the appearance of fine lines and wrinkles

Hydrolyzed collagen:

Improves appearance of aged and blemished skin.

Palmitoyl tripeptide-38:

Improves appearance of skin, fine lines, and wrinkles from the inside particularly on the forehead and crow's feet. In-vitro studies have found a matrikine-like effect that stimulates the synthesis of six major proteins including collagen I, II, IV, fibronectin, hyaluronic acid and laminin 5.

Palmitoyl tripeptide-5:

In-vitro tests showed that tripeptide has better collagen building capacity than TGF-beta. Has good skin firming and moisturizing properties.

Tetrapeptide 30:

Anti-aging products with correction of age spots and pigmentation.

Nano liposomal Resveratrol:

Nano liposomal Resveratrol has a particle size of less than 30nm, and enables the resveratrol to be steadily encapsulated in nano-carriers, greatly improving the absorption efficiency and bioavailability. Resveratrol is a natural polyphenol and powerful antioxidant. Has been found to reduce the appearance of aging skin due to its good antioxidant effects.

Basement Membrane Zone (Fig 1)

NMF Diagram

Science Q&A: NMF Hydrator

What does NMF stand for and what role does it play in skin health?

A: Natural moisturizing factor (NMF) is essential for appropriate karotinocyte hydration, barrier homeostasis, minimization of trans-epidermal water loss and cellular health.

The role of NMF is to maintain adequate skin hydration. Adequate hydration of the Stratem Cornium serves three major functions:

1. Maintain plasticity of the skin, protecting it from damage.
2. Allows Hydrolytic enzymes to function on the process of desquamation.
3. Contributes to optimum Stratum Corneum function.

Is NMF necessary for the skin barrier to be healthy?

A: The skin barrier is crucial for ensuring the skin looks and feels healthy and hydrated. It's your bodys first line of defense against environmental pollutants, toxins, micro-organisms and allergens that your skin is exposed to everyday. Disruption of the barrier results in inflammation infection and several dermatological diseases.

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RXR Retinol Anti-Aging Serum Science

    Benefits

  1. Promotes healthy cellular turnover and renewal
  2. Minimizes the appearance of pores and blackheads
  3. Diminishes the appearance of fine lines and wrinkles
  4. Evens texture and tone

learn more below! ↓

Ingredients:

Distilled water, Squalane, C12-15 alkyl benzoate, propanediol1 3 sodium acrylate/ sodium acryloyldimethyl taurate copolymer, Glycerin, Retinol, Glycine soja, Glyceryl stearate, PEG-100 stearate, Niacinamide, Lactic acid, Arnica Extract, Hyaluronic acid, Resveratrol, kojic acid, CoQ10, Phenoxyethanol, Nannochloropsis oculate extract, pullulan, Palmitoyl tripeptide-5, Cellulose gum, acrylates/ c10-30 alkyl acrylate crosspolymer, Chitosan, Glycolic acid, Polysorbate 20, Sorbitan oleate, BTH, C15-19 alkane, Polyglyceryl-6 laurate, Polyglycerin-6, Ethylhexylglycerin, hydrolyzed collagen, Polypodium leucotomas, Melatonin, Sodium benzoate, Potassium sorbate, Caprylyl glycol

1: Promotes healthy cellular turnover and renewal

L-Ascorbic acid:

Exfoliates skin surface pigmentation for a more even tone and brighter complexion. Proven to help prevent appearance of new dark spots.

CoQ10:

Powerful antioxidant to protect from environmental stressors and induction of collagen synthesis.

Polypodium Leucotomos:

A natural plant based extract derived from the fern leaf that protects DNA from the harmful effects of UV light and environmental pollutants.

2: Minimizes the appearance of pores and blackheads

Vitamin A (Retinol):

Promotes cellular turnover and stimulates collagen synthesis to diminish the appearance of fine lines and wrinkles. (Figure 2)

Lactic acid:

Can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged pores

3: Diminishes the appearance of fine lines and wrinkles

Melatonin:

A hormone naturally made in the pineal gland that helps with sleep but does not induce sleep when applied topically. When we sleep, our bodies go into restoration mode with increased cellular rejuvenation and energy repletion. This powerful antioxidant has the same effect on the skin. It helps increase antioxidant enzyme production and supports our natural repair functions.

4: Evens texture and tone

Tripeptide-5:

Stimulates synthesis of collagen and elastin to smooth and firm skin.

RXR Retinol (Fig 2)

Retinol Diagram

Science Q&A: RXR Retinol

Q: What's the difference between retinol, retinaldehyde and retonic acid and how does it effect the skin?

A: Retinol is a type of retinoid- a class of Vitamin A derivatives used in dermatology. Retinoic acid (Tretinoin), Adapalene, and Tazrotene are forms of Vitamin A that are frequently used in dermatology. Retinol and Retinaldehyde are both considered cosmeceutical forms of Vitamin A and are often used in skincare products for their anti-aging effects. Although less potent than Tretinoin (which is prescription strength), both forms get converted to Retinoic Acid in the skin. Retinol and Retinaldehyde get converted back and forth to one another but both end up getting converted to Retinoic Acid. The formulation, stabilization and delivery mechanism of Retinol greatly affects its efficacy and side effect profile. This results in its powerful anti-aging benefits without the irritation of a prescription strength Retinoic Acid. This is due to less extracellular product to minimize irritation and greater efficacy from more internuclear retention of the product. Retinol binds the Retinol-RPB (Retinol binding complex) which enters the cell through a RBP receptor complex (STRA6). Once it enters the cell nucleus, it binds a heterodimer which is made up of the RAR and RXR receptors. This results in the transcription and translation of genes that encode proteins with powerful anti-aging effects. Our elegant formulation of Retinol provides molecular stabilization and amplified efficacy. Our proprietary blend with CoQ10, a powerful antioxidant augments the production of collagen and elastin in the extracellular matrix giving skin a smooth tight texture. Polypodium leukotomas, a newly discovered plant based enzyme protects the newly synthesized collagen from within. The blend of these powerful anti-aging ingredients work synergistically to restore and protect the skin. Retinol is one of the best studied cosmeceuticals with many known skin benefits. Benefits include the stimulation of collagen synthesis, decreasing the appearance of fine lines and wrinkles, reduction in pore size, diminished acne, increased hydration, lightening pigmentation, reducing atypical cells and improving texture. Retinol is best used at bedtime. Although, unlike its relative tretinoin which gets inactivated by sunlight, Retinol can also be safely used in the morning as well. When starting out, nightly use is preferred over twice daily use until your skin gets used to it to minimize irritation. **Not Pregnancy Safe

Q: What is cellular turnover?

A: Cellular turnover in the skin is important because this keeps the skin looking bright and fresh. The time that it takes a baby stem cell to develop into a corneocyte and exfoliate off the epidermis is called the "transepidermal time". In kids its 14 days, in teens it's 28 days and in adults its between 28-42 days. The faster the cellular turnover, the faster the transepidermal time, the fresher the skin cells, and the brighter and healthier the skin looks. That's why in older patients skin can look dull, dry, and listless. Those cells become more scienescent and lazy. They need to be simulated to behave younger and become more active in synthesizing collagen and renewing themselves. Babies and kids have fresh bright viable skin. This is why. Those cells are active! Under the microscope, patients over 40 have a slower transepidermal time and the cells are sluggish compared to younger patients. However, a patient over forty who uses a Retinol will have cells that look like that of a younger patient under the microscope. This correlated with youthful looking skin clinically as well.

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Vitamin C-FK Brightening Complex Science

Benefits

  1. Promotes an even skin tone by fading hyperpigmentation and brightening complexion.
  2. Powerful antioxidants help defend against environmental damage.
  3. Diminishes the appearance of fine lines and wrinkles.

learn more below! ↓

Ingredients:

Distilled Water, Ethoxydiglycol, L-ascorbic acid, Laureth-23, Glycerin, Licorice root extract, Kakadu plum extract, Kojic acid, Ferulic acid, Triethanolamin, Polyacrylate crosspolymer-6, Tetrahexyldecyl ascorbate,3-glyceryl ascorbate, Magnesium ascorbyl phosphate, Gotu kola extract, Vitamin e, Phenoxyethanol, Sorbic acid, Xanthan gum, Hyaluronic acid, lchorium intybus root oligosaccharides, Nano liposomal Resveratrol, Caesalpinia spinosa gum, Sodium benzoate, Gluconolactone, EDTA

1: Promotes an even skin tone by fading hyperpigmentation and brightening complexion

L-Ascorbic acid:

Exfoliates skin surface pigmentation for a more even tone and brighter complexion. Proven to help prevent appearance of new dark spots. (figure 3)

Ferulic Acid:

Corrects hyperpigmentation and increases the stability and absorption of the Vitamin C.

Kojic acid:

Because of its melanin-blocking properties, kojic acid is helpful with treating and preventing hyperpigmentation of all types.

2: Powerful antioxidants help defend against environmental damage

Nano liposomal Resveratrol :

Resveratrol is a plant-based polyphenol and powerful antioxidant.

Lactic acid:

Can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged pores.

Kakadu plum:

Kakadu plum extract reduces redness and inflammation. This makes Kakadu ideal for sensitive skin types, especially those with inflammatory conditions like acne or eczema.

Licorice root extract:

Acts as a potent antioxidant: Like many other plant-based extracts, licorice contains a flavonoid, an antioxidant-rich component that decreases reactive oxygen species, which both age and discolor the skin.

Gotu Kola:

Gotu kola is rich in triternene saponins—a compound that helps keep skin tighter and firmer—and is also a great source of phytonutrients called flavonoids that act as antioxidants and fight off free radical damage. It boosts the formation of collagen and skin tissue, which is crucial in maintaining the skin’s elasticity and youthful glow. Another benefit that gotu kola is most known for is its ability to improve blood circulation. This speeds up the skin’s healing process.

3: Diminishes the appearance of fine lines and wrinkles.

lchorium intybus root oligosaccharides:

Shown to have an immediate and medium term tightening effect on the skin thanks to sequential release of the active ingredient.

4: Utilizes multiple forms of vitamin c, Kojic acid and Resveratrol to maintain efficacy with a powerful and effective delivery system.

L-Ascorbic acid:

Exfoliates skin surface pigmentation for a more even tone and brighter complexion. Proven to help prevent appearance of new dark spots.

Tetrahexyldecyl ascorbate:

Highly stable, oil-soluble vitamin C ester. Has excellent skin penetration and as a result offers increased cell protection against UV-B. Unlike pure vitamin C (l-ascorbic acid), tetrahexyldecyl ascorbate is lipid (fat) soluble. As such, it can penetrate further into skin where it works with vitamin E (tocopherol) that’s naturally in your skin or in skin care products to target skin’s underlying support system via a different pathway than water-soluble ascorbic acid.

3-glyceryl ascorbate:

This form shares many of the same benefits as regular vitamin C, including being an antioxidant, improving skin tone, helping to fade hyperpigmentation and post-breakout marks, and supporting skin’s firmness.

Magnesium ascorbyl phosphate:

Magnesium ascorbyl phosphate, as a vitamin C derivative, offers cosmetic stability and is metabolized to vitamin C after penetrating the skin. In addition to its effect as a radical scavenger, magnesium ascorbyl phosphate is used to lighten the skin and to support collagen synthesis.

Kojic acid:

Because of its melanin-blocking properties, kojic acid is helpful with treating and preventing hyperpigmentation of all types.

Nano liposomal Resveratrol:

Resveratrol is a plant-based polyphenol and powerful antioxidant

Vitamin C-FK (Fig 3)

Vitamin CDiagram

Science Q&A: Vitamin C-FK Brightening Complex

Q: What forms of vitamin C are in the vitamin C-FK complex?

A: It contains all 4 forms of vitamin C including 15% L-ascorbic acid, Tetrahexyldecyl ascorbate, 3-glyceryl ascorbate, and magnesium ascorbyl phosphate. MDAIRE technology provides an innovative proprietary formulation to deliver maximum absorption and stabilization. Vitamin C is a highly unstable molecule. Therefore the delivery mechanisms and stability of the product become very important. Our unique formulation ensures effective delivery of Vitamin C to exactly where it needs to go in a formulation which allows it to remain molecularly stable and bioavailable once it gets there. The integrity of this innovative blend of Vitamin C is protected in an airless pump to minimize oxidation of the product which can occur if the product is exposed to air. Once applied to the skin, you will notice instantly how fast the product gets absorbed into the skin. It does not pill under sunscreen or make up. **Safe for pregnancy

Q: Why are antioxidants necessary for the skin

A: Antioxidants are important in the skin for several reasons. Antioxidants are free radical scavengers. This means they prevent skin cancer and atypical cellular activity. They prevent structural damage to the skin by protecting collagen and elastin from breaking down from free radical damage. It protects the skin from environmental pollutants and ultraviolet damage. Antioxidants makes skin cells healthy and healthy skin is free of sun damage, wrinkles and textural irregularities.

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Regenerative ECM Eye Complex Science

Benefits

  1. Stimulates the production of healthy new collagen and elastin
  2. Helps clear the extracellular matrix of damaged and dysfunctional collagen and elastin fibers
  3. Reduces the appearance of dark circles, puffiness and wrinkles

learn more below! ↓

Ingredients:

Distilled water, Niacinamide, B3, Glycerin, Propanediol 1 3, Glyceryl stearate, Green tea butter, Green tea extract,PEG-100 stearate, Sodium acrylate / sodium acryloyldimethyl taurate copolymer, Squalane, Nannochloropsis Oculata extract, Pullulan, Polysorbate 80, C12-15 alkyl benzoate, Meadowfoam seed oil, Licorice root extract, Caffeine, White tea extract, Colloidal oatmeal, Isohexadecane , Vitamin e, Phenoxyethanol, Polypodium leucotomos,Acetyl hexapeptide-3,Steareth-20, N-hydroxysuccinimide, Chrysin, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Chlorhexidine digluconate, Xanthan gum, Hydroxypropyl cyclodextrin, palmitoyl tripeptide-38,Palmitoyl tripeptide-5, Sodium benzoate, Potassium sorbate

1: Stimulates the production of healthy new collagen and elastin

Palmitoyl tripeptide-5:

In-vitro tests showed that tripeptide has better collagen building capacity than TGF-beta. Has good skin firming and moisturizing properties.

2: Helps clear the extracellular matrix of damaged and dysfunctional collagen and elastin fibers

Green Tea Extract:

Potent antioxidants and polyphenols to repair and correct damaged DNA.

Polypodium Leucotomos:

A natural plant based extract derived from fern leaves that protects DNA from the harmful effects of UV light and environmental pollutants.

3: Reduces the appearance of dark circles, puffiness and wrinkles

Niacinamide :

reduces the appearance of fine lines and wrinkles. Improves the appearance of aged hyper pigmented and photo damaged skin.

Caffeine:

Helps to reduce inflammation, puffiness and wrinkles, it also tightens and brightens the skin..

Acetyl hexapeptide-3:

Works through a unique mechanism which makes the skin looks firm and tight. Can reduce the appearance of superficial facial lines and wrinkles with regular use. (Figure 4)

Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7:

Can reduce the appearance of dark circles under the eyes and reinforce firmness and tone of the eye area

Palmitoyl tripeptide-38:

Improves appearance of skin relief, fine lines, and wrinkles from the inside particularly on the forehead and crow's feet. In-vitro studies have found a matrikine-like effect that stimulates the synthesis of six major proteins including collagen I, II, IV, fibronectin, hyaluronic acid and laminin 5

Regenerative ECM Eye Complex (Fig 4)

Eye Serum Diagram
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Neck Tyte-R Science

Benefits

  1. Tightens, firms and smooth skin on the neck and decolletage
  2. Erases and corrects brown spots, redness and sun damage
  3. Reverses damage and helps protects against future damage to neck and chest skin
  4. Improves the appearence of crepiness, laxity and texture

learn more below! ↓

Ingredients:

Deionized water, Squalane, Propanediol 1-3, Meadowfoam seed oil, Dimethicone, Glycerin, Mulberry root extract, Algae extract, Ceramide NP, ceramide AP, Glycoprotines, Cetearyl Olivate, Sodium hyaluronate, Sorbitan Olivate, Acetyl hexapeptide-8, Agave Rigida extract, Acetyl Hexapeptide-30, Arginine, Dextran, Ceramide EOP, phytosphingosine, Trifluoroacetyl Tripeptide-2, Hydrolyzed Eragrostis Tef Seed Extract, Palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine, palmitoyl dipeptide-5 diaminohydroxybutyrate, Palmitoyl Tripeptide-38, Caprylyl glycol, Retinol, Tripeptide-5, Bakuchi fruit extract, Ethylhexylglycerin, resveratrol, cholesterol, sodium lauroyl lactylate, carbomer, Polypodium leucotomos, xanthan gum, cellulose gum, sorbic acid, Phenoxyethanol, acrylates/ c10-30 alkyl acrylate crosspolymer, Melatonin, chitosan, glycolic acid, polysorbate 20, sorbitan oleate

1: Tightens, firms and smooth skin on the neck and decolletage.

Palmitoyl tripeptide Complex:

Palmitoyl tripeptide peptides act on specific skin receptors and stimulate the synthesis of collagen. They smooth and tighten the skin to reduce the appearance of wrinkles and fine-lines.

Acetyl hexapeptide-8:

This peptide is like botox in a bottle. It helps smooth the skin by relaxing the smooth muscles under the skin. It also promotes collagen synthesis and optimizes the function of collagen helping to fight fine lines, laxity and improve moisture levels in the skin. Also known as Argirline.

Tef Seed Extract:

A natural peptide specifically designed to address fragile skin areas such as neck and decollete. A clinically proven ingredient to increase the production of collagens and reinforce the dermal-epidermal junction (DEJ) to enhance skin firmness, tonicity and elasticity on neck.

2: Erases and corrects brown spots, redness and sun damage.

Glycolic acid:

An exfoliating alpha hydroxy acid that works both on the surface of your skin and in the deeper layers of your skin. With gentle exfoliation it can refine skin tone by visibly reducing brown spots and sun damage.

Microencapsulated Retinol Complex:

Promotes cellular turnover and stimulates collagen synthesis to diminish the appearance of fine lines and wrinkles.

3: Reverses damage and helps protects against future damage to neck and chest skin.

Polypodium Leukotomas:

A natural plant based extract derived from the fern leaf that protects DNA from the harmful effects of UV light and environmental pollutants (Figure 4A)

Topical Melatonin:

A hormone naturally made in the pineal gland that helps with sleep but does not induce sleep when applied topically. When we sleep, our bodies go into restoration mode with increased cellular rejuvenation and energy repletion. This powerful antioxidant has the same effect on the skin. It helps increase antioxidant enzyme production and supports our natural repair functions. (figure 4B)

4: Improves the appearence of crepiness, laxity and texture.

Acetyl hexapeptide 8 (aka Argirline):

This peptide is like botox in a bottle. It helps smooth the skin by relaxing the smooth muscles under the skin. It also promotes collagen synthesis and optimizes the function of collagen helping to fight fine lines, laxity and improve moisture levels in the skin. Also known as Argirline.

Necktyte-R (Fig 4 A/B)

NecktyteRDiagram

Science Q&A: NeckTyte-R

Q: Why do I need a specialized product for my neck and decollete? Why can't I just use my other products like my NMF Hydrator Barrier Repair or Vitamin
C-FK Brightening Complex?

A: The neck and chest skin is different from the skin on your face. Neck skin histology, which is the microscopic structure of tissues in this skin, is different from the skin on your face. It is thinner, more susceptible to damage, and it lacks sebaceous glands. This means that it requires different active ingredients and different vehicle delivery systems. MDAiRE™ Neck Tyte-R complex addresses these issues by using peptides that demonstrate neuromodulator effects, integrating a heavier use of DNA repair enzymes, and remaining focused on barrier restoration and NMF's (natural moisturizing factors). The neuromodulator effects of the peptides in the MDAiRE­™ Neck Tyte-R effect the innervation (stimulation) of the neck muscles and overlying skin to give a smooth instead of textured appearance to the delicate crepey skin of the neck and decollete. The thinner skin of the neck and decollete require a heavier use of DNA repair enzymes and peptide complexes to reverse the sun and environmental damage that has taken place. Hydration of your skin on your neck and decollete skin will make your skin appear smoother and supple.

Q: Are there certain antioxidants that are more important to use on the neck and decollete?

A: Topical Melatonin and Polypodium leukotomoas have been shown to be more effective and powerful antioxidants for the specific neck and decollete area. Polypodium leukotomoas is a natural plant based extract derived from the fern leaf that protects DNA from the harmful effects of UV light and environmental pollutants. Melatonin is a hormone naturally made in the pineal gland that helps with sleep but does not induce sleep when applied topically. When we sleep, our bodies go into restoration mode with increased cellular rejuvenation and energy repletion. This powerful antioxidant has the same effect on the skin. It helps increase antioxidant enzyme production and supports our natural repair functions. It is an effective defense against UV rays and helpful for anti-aging goals. Antioxidants such as Vitamin C or L-ascorbic acid can be irritating and proinflammatory to the delicate skin of your neck and decollete.

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